Spontaneous regression of keratoacanthoma can be promoted by topical treatment with imiquimod cream.
نویسندگان
چکیده
Imiquimod, the first member of a new class of immune response modifiers, is approved for the treatment of external genital and perianal warts. Recently, many clinical trials highlighted the potential of imiquimod as a treatment for other viral infections and cutaneous neoplasms. We report two cases of facial keratoacanthomas (KA) treated with topical 5% imiquimod cream. Patients were successfully cleared of KAs after treatment for 8 weeks. No recurrence occurred after a 1-year follow-up. Despite the fact that KAs are characterized by the potential for spontaneous regression, it is possible that a faster activation of CD4+ lymphocytes, via interferon release and cytokine secretion takes place after imiquimod application leading to KA regression.
منابع مشابه
Treatment of Keratoacanthoma with 5% Imiquimod Cream and Review of the Previous Report
Keratoacanthoma (KA) is a benign epidermal tumor, characterized by rapid and abundant growth, a tendency toward spontaneous regression and histopathologic similarity to squamous cell carcinoma (SCC). Because KA can be easily misdiagnosed as SCC, surgery is considered the treatment of choice. Recently, regression of KAs following application of 5% imiquimod cream (Aldara®) has been reported. We ...
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ورودعنوان ژورنال:
- Journal of the European Academy of Dermatology and Venereology : JEADV
دوره 18 5 شماره
صفحات -
تاریخ انتشار 2004